Rémi BOS

Neuroglial Interactions and Spinal Circuit Dynamics

I am a neurobiologist at CNRS (Biology Department, Section 27) working at the Timone Neuroscience Institute (INT, Marseille, France) within the SpiCCI team (Spinal Cord and Cerebrospinal Fluid Interface). My research investigates how glial cells and neurons interact within the spinal cord to regulate sensorimotor and autonomic functions. We study how these interactions, shaped by metabolic cues, cerebrospinal fluid signals, and inflammatory processes, contribute to spinal network plasticity in health and disease.

My current work focuses on three complementary themes:

1. Glio-glial crosstalk in spinal rhythmicity, uncovering how radial glia and astrocytes coordinate locomotor network synchronization.
2. Neuroglial mechanisms in sensorimotor integration, deciphering how astrocytes modulate inhibitory synaptic transmission within spinal circuits
3. Neuroimmune and metabolic interfaces, investigating how glia at the central canal sense and respond to inflammatory or metabolic stress, influencing cerebrospinal fluid dynamics and sensorimotor/autonomic processing.

By combining two-photon/confocal imaging, electrophysiology, genetic tools, and behavioral approaches, we study the spinal cord as a living, dynamic system where neurons, glia, and fluids continuously interact. This integrative approach bridges cellular neurophysiology, bioengineering, and translational neuroscience, with the goal of better understanding spinal circuits dynamics and identifying new therapeutic strategies for spinal and neuroinflammatory disorders.

In 2025, I was honored with the CNRS Bronze Medal for my contributions to understanding spinal neuroglial dynamics.

Beyond my core research, I am committed to science outreach, as well as fostering equity and inclusion in science.

 
Learn more:

List of publications
Detailed CV

Neuroglial interactions
Spinal circuit dynamics
Multi-scale approaches