Lancement de l’essai clinique SpasT-SCI-T par l’équipe MRS

A blood biomarker to diagnose traumatic CNS injuries and predict spasticity.

Background:
Spasticity complicates recovery after spinal cord or traumatic brain injury and significantly impacts quality of life of patients.
Study objective:
To validate new blood biomarkers derived from sodium channel degradation (by calpain) to:
– Assess the severity of spinal cord injury or traumatic brain injury.
– Predict the risk and progression of spasticity

This study is performed in close collaboration with the Departments of Neurosurgery, Intensive Care, and Physical Medicine and Rehabilitation.

Baucher G, Liabeuf S, Brocard C, et al. (2025) The SpasT-SCI-T trial protocol: Investigating calpain-mediated sodium channel fragments as biomarkers for traumatic CNS injuries and spasticity prediction. PLOS One.