Séminaire de Michel Dallaporta 08/03/2024

Friday 8th March 2024, at 14:30 in Gastaut meeting room

Michel Dallaporta (Cognitive Neurosciences Laboratory)

(invited by Franck Debarbieux)

Glial cells, partners of energy balance regulation, and probably more!

Abstract:
The CNS is known to control feeding and body weight and to allow glucose homehostasis. In this context, during the two last decades, the contribution of neuroglial interactions appears to be crucial to avoid the right regulation in responses to imbalance. More precisely, the glial compartment in the hypothalamus and the dorsal vagal complex (DVC), a brain structure involved in vegetative regulation, seems to play a key role in these regulations. Effectively,my results have shown that astrocytes subpopulations such as tanycytes in the hypothlamus or vagliocytes in the DVC, are able to sense differents humorals signals such as leptin or food toxins in order to induce metabolic and behavioral responses . Moreover, microglial cells present near circumventricular organs (CVOs), seems also come into play in the activaton of subjacent brain structures and this in collaboration with the astrocytes compartment. Taken together, these observations leads to consider the multifaced glial compartment, particularly at DVC level, as an important integrator in feeding-related processes and underlines the importance of inflammatory phenomena for the regulation of feeding behavior. Whereas DVC inflammation occurs in regions without BBB wich are also in close relationships with the cerebro-spinal fluid, I hypothesize that this local microglial/astroglial activation can also impact remote brains structures through cytokine or hormonal communication. Different functions such as locomotor activity, emotional and motivational behavior might be modulated by the inflammatory status of the brainstem structures and CVOs that I have studied so far. That’s what I could help to investigate when joining INT and more precisely in the field of spinal cord trauma.