Séminaire de Salah El Mestikawy
Friday 18th November at 2:30 PM, INT, salle Henri Gastaut
Salah El Mestikawy, The Douglas Research Centre – McGill University, Montreal Canada)
(invited by Christelle Baunez)
Investigations of a rare variant of VGLUT3 (p.T8I) provide a model for a molecular understanding of addiction and eating disorders and opens the doors to specific treatments
Cholinergic interneurons are pivotal regulators of striatal function and have the particularity to express both the vesicular acetylcholine transporter (VAChT) and the atypical type 3 vesicular glutamate transporter (VGLUT3). We previously identified the missense polymorphism p.T8i (a change from a threonine at position 8 to an isoleucine) in patients with severe addiction or eating disorders. In this study we found: i) that this allele is causative in psychiatric disorders, ii) what are the underlying neurochemical mechanisms and iii) a treatment to alleviate ED in rodent and potentially in humans.