Séminaire de Timothée LEVI

Jeudi 12 juin 2025, 12h-14h, salle Laurent Vinay, INT

Timothée LEVI (IMS, University of Bordeaux)

Biomimetic neuromorphic systems for real-time closed-loop bio-hybrid systems

Abstract: Millions of people worldwide are affected by neurological disorders which disrupt connections between brain and body causing paralysis or affect cognitive capabilities. Such a number is likely to increase in the next years and current assistive technology is still limited. Since last decades Brain-Machine Interfaces (BMIs) and generally neuroprosthesis have been object of extensive research and may represent a valid treatment for such disabilities. The realization of such prostheses implies that we know how to interact with neuronal cell assemblies, considering the intrinsic spontaneous activity of neuronal networks and understanding how to drive them into a desired state or to produce a specific behavior. The long-term goal of replacing damaged brain areas with artificial devices also requires the development of biomimetic neuromorphic systems. They will fit with the recorded electrophysiological patterns and will produce in their turn the correct stimulation patterns to the biological network so as to recover the desired function. First, we will describe the implementation of biologically realistic cell models. This digital implementation computes in real-time, and is freely configurable. Second, the description of bio-hybrid systems and applications of bio-hybrid experiments using our system for real-time bidirectional communication with biological cells and for application to new generation of AI.
Reference: R. Beaubois et al., “BioemuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network. Nat Commun 15, 5142, 2024. S. Buccelli et al., “A neuroprosthetic system to restore neuronal communication in modular networks”, iScience, 19, 2019